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There is someone who supports me, even though I lack the talent.
|― Yotsuba Nakano|
Yotsuba Nakano (
AppearanceYotsuba is a carefree and cheerful looking girl with a short straight hair. She has a consistent light orange hair color throughout Volume 1 to Volume 4. Her notable accessories is an ear-shaped ribbons. Like her sisters, she has a dark blue eyes, an average height, a well-endowed figure and large breasts.
Fuutarou Uesugi calls Yotsuba's ribbon as an eyesore. Yotsuba still wears her ribbon when bathing. Yotsuba change into a new ribbon because it's the new trend. Yotsuba's ribbon changes form depending on her emotion.
Yotsuba wears her uniform with a large butterfly-shaped tie and wears a sports bag. It is revealed by Ichika Nakano that Yotsuba still uses her panties from elementary school days. Yotsuba's bedroom is the only one that hasn't been revealed from the initial tour. We can see her room after the Labour Thanksgiving Tour date with Yotsuba. She uses animal-shaped pajamas. According to Ichika, Yotsuba still uses childish panties.
Yotsuba is an active, cheerful and easygoing girl. She talks in a loud, spontaneous and sometimes absent-minded manner. She is a type of person who can't say no to people who need help. She is mostly seen helping people either directly and indirectly.
Yotsuba is good at sports, the basketball club even asked her to join the team. Yotsuba's excellent sports skill is shown, she scores 7.9 seconds for a 50m sprint. Yotsuba is getting praised as a skilled player by a basketball club member. She also has excellent stamina and is a good runner. Yotsuba is the only known sister with excellent eyesight (Itsuki Nakano wears glasses and Nino Nakano use contacts). Yotsuba got a part-time job in cleaning-related work. Yotsuba is good at festival games. Yotsuba's excellent eyesight is shown again, she is able to recognize the nametag on Nino's uniform from the second floor. Miku Nakano will notice if Yotsuba is lying to her, because according to Fuutarou Uesugi, Yotsuba is bad at lying. Yotsuba's poor academic abilities are first hinted and shown, she gets a zero for a test. Yotsuba remarks that she is the one most likely to repeat a year. Yotsuba's excellent eyesight and kind attitude is shown for the first time, she notices a test paper Fuutarou dropped and returns it to him.
Yotsuba states that she is the dumbest among the sisters. Among the sister, Yotsuba is ranked the lowest one with her strongest subject is Japanese. Yotsuba is bad at lying, though she states that she could do it if she really tries to lie. Yotsuba is good at Summer Festival games.
- "I'll support you with everything I've got!"
- "As long as you are here, there is no need to worry"
- "Do you forget that even though I'm like this, I'm still a genuine girl?"
- "I'm sorry Uesugi-san, but I can't ignore people in trouble!" 
- "There's someone, supporting an untalented girl like me"
- "In questions with five choices, chances are highest it's the fourth answer!"
- "It's because I like you"
- "If you love us, you'll just naturally be able to tell"
- "The important thing isn't where we are, it's that the five of us are together."
- "I love the view you get here when you swing as hard as you can. It's not the same as those million dollar views they talk about. But when I imagine that each of those lights is a family, it warms my heart."
- "An idiot like me can be helpful to everyone? I won't be the me who just hold everyone back anymore?" 
- "It feels like.. my efforts have been rewarded for the first time ever"
- "Even though you were an unlikable boss who always wanted what others had, you were our leader. I've always thought of you as the older sister since back then."
- "Don't feel like you should be the only one holding yourself back. Just do whatever you want to do."
- "Even you might find someone you love in the future, Uesugi-san. And when that happens, no matter who you love, no matter how you come to love them, I'll always be on your side.. supporting you with everything I've got!"
- The name Yotsuba means "four" (四) (yotsu) and "leaf" (葉) (ba).
- Yotsuba is the first Nakano Quintuplets who directly or indirectly confesses to Fuutarou Uesugi, although she dismissed it as a joke.
- Yotsuba has a unique giggle: "Shi Shi Shi". This is a pun on number 4.
- Yotsuba has a shirt with the number "428" screened on it. This is a pun on her name's reading (Yo-Tsu-Ba).
- Yotsuba is the first Nakano Quintuplets who has a one-on-one date (although not romantically) with Fuuutarou.
- Yotsuba's voice actor, Ayane Sakura, once voiced all five girls for a television commercial for the manga in October 2017.
- Yotsuba is the third Nakano Quintuplets who is seen crying in front of Fuutarou. The first being Ichika Nakano in Chapter 27 and the second is Nino Nakano in Chapter 43.
- Yotsuba is the first one who tried to dress differently several years ago.
- Yotsuba is the only Nakano Quintuplets so far to not harbor any romantic feelings towards Fuutarou as all of what she does on Fuutaro because she feels like it.