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There is someone who supports me, even though I lack the talent.
— Yotsuba Nakano
Yotsuba Nakano (
AppearanceYotsuba has short, straight hair that stops just around her neck. She is portrayed to have light orange hair color throughout Volume 1 to Volume 4. Her notable accessory is a bunny ear-shaped ribbon, which can change forms depending on her emotions. Like her sisters, she has dark blue eyes, an average height, a well-endowed figure, and large breasts.
Yotsuba wears her uniform with a large butterfly-shaped tie and wears a sports bag. It is revealed by Ichika that she still uses her panties from elementary school days. She uses small-shaped pajamas.
Yotsuba is an active, cheerful and easygoing girl. She talks in a loud, spontaneous and sometimes absent-minded manner. She is the type of person who can't say no to people who need help, and is mostly seen helping people either directly and indirectly.
While cheerful on the outside and towards others, Yotsuba also harbors feelings of inferiority towards her sisters and her own abilities. Her inferiority complex started to grow when she met Fuutarou when they were children, and caught him talking to her sister all the while noticing that he did not know it wasn't her. She had made several attempts to fix her complex (such as putting her iconic ribbons and trying to excel in extra-curricular activities), which in turn made her desire to be different from her sisters grow stronger. While portrayed as a bad liar early on, she is later shown to have some skill in lying herself; being able to hide her true identity to Fuutarou all the while being able to maintain their relationship, at least when together.
Yotsuba is good at sports, the basketball club even asked her to join the team. Yotsuba's excellent sports skill is shown, she scores 7.9 seconds for a 50m sprint. Yotsuba is getting praised as a skilled player by a basketball club member. She also has excellent stamina and is a good runner. Yotsuba is the only known sister with excellent eyesight (Itsuki Nakano wears glasses and Nino Nakano uses contacts). Yotsuba got a part-time job in cleaning-related work. Yotsuba is good at festival games. Yotsuba's excellent eyesight is shown again, she is able to recognize the nametag on Nino's uniform from the second floor. Miku Nakano will notice if Yotsuba is lying to her, because according to Fuutarou Uesugi, Yotsuba is bad at lying. Yotsuba's poor academic abilities are first hinted and shown, she gets a zero for a test. Yotsuba remarks that she is the one most likely to repeat a year. Yotsuba's excellent eyesight and kind attitude are shown for the first time, she notices a test paper Fuutarou dropped and returns it to him.
Yotsuba states that she is the dumbest among the sisters. Among the sister, Yotsuba is ranked the lowest one with her strongest subject is Japanese. Yotsuba is bad at lying, though she states that she could do it if she really tries to lie. Yotsuba is good at Summer Festival games.
- Main Article: Yotsuba Nakano/Relationships
- "I'll support you with everything I've got!"
- "As long as you are here, there is no need to worry"
- "Do you forget that even though I'm like this, I'm still a genuine girl?"
- "I'm sorry Uesugi-san, but I can't ignore people in trouble!" 
- "There's someone, supporting an untalented girl like me"
- "In questions with five choices, chances are highest it's the fourth answer!"
- "It's because I like you"
- "If you love us, you'll just naturally be able to tell"
- "The important thing isn't where we are, it's that the five of us are together."
- "I love the view you get here when you swing as hard as you can. It's not the same as those million dollar views they talk about. But when I imagine that each of those lights is a family, it warms my heart."
- "An idiot like me can be helpful to everyone? I won't be the me who just hold everyone back anymore?" 
- "It feels like.. my efforts have been rewarded for the first time ever"
- "Even though you were an unlikable boss who always wanted what others had, you were our leader. I've always thought of you as the older sister since back then."
- "Don't feel like you should be the only one holding yourself back. Just do whatever you want to do."
- "Even you might find someone you love in the future, Uesugi-san. And when that happens, no matter who you love, no matter how you come to love them, I'll always be on your side.. supporting you with everything I've got!"
- The name Yotsuba means "four" (四) (yotsu) and "leaf" (葉) (ba).
- Yotsuba has a unique giggle: "Shi Shi Shi." This is a pun on number 4.
- Yotsuba has a shirt with the number "428" screened on it. This is a pun on her name's reading (Yo-Tsu-Ba).
- Yotsuba's voice actor, Ayane Sakura, once voiced all five girls for a television commercial for the manga in October 2017.
- In the one-shot, Yotsuba has longer hair.