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Fuutarou Uesugi is a poor & anti-social top student. One day, he gets a job tutoring a rich family that's new to the town. Fuutarou's soon-to-be students are revealed to be his new classmate, Itsuki Nakano, and her quintuplet sisters. Despite the girls' poor first impression of Fuutarou, he tries seriously to do his job, only to find they have terrible grades and terribly complex personalities.
Ayane Sakura initially planned to voice all of the quintuplets in the anime. This was ultimately not implemented due to concerns over the stress that having to voice all the quintuplets would cause to Sakura's voice and throat. Source